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[Nilde-fornitrici] RICHIESTA ARTICOLO
- Subject: [Nilde-fornitrici] RICHIESTA ARTICOLO
- From: Elena Maria Alaimo <Elena.Alaimo@marionegri.it>
- Date: Thu, 12 Jun 2025 07:23:47 +0000
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Gentili colleghe/i,
dopo infruttuosa ricerca nei cataloghi chiedo gentilmente un aiuto per recuperare il seguente articolo:
Author
Chiang, S. L. Lee, C. P. Chang, J. G. Lee, C. H. Yeh, K. T. Tsai, Y. S. Chen, M. K. Chen, C. H. Ko, Y. C.
Year
2013
Title
Joint effects of differentiation factor 15 and substance use of alcohol, betel-quid and cigarette on risk of head and neck cancer
Journal
Head & Neck Oncology
Volume
5
Issue
3
Abstract
Growth differentiation factor 15 (GDF15) is susceptible to areca nut exposure in oral cells and contributes in the oral tumor progression. Here, we determined whether independent and joint effects between GDF15 and substance use of alcohol, betel-quid, and cigarette (ABC) influence the incidence of squamous cell carcinoma of the head and neck (SCCHN). Serum level and genetic variants of GDF15 and substance use habits were evaluated in risk of SCCHN using a case-control study with 1,191 hospital-based volunteers. Serum GDF15 level showed an increasing trend among controls and SCCHN patients with different cancer stages (Ptrend<0.0001). Furthermore, it was positively correlated with lifetime consumption of alcoholic beverages, betel-quid and cigarettes in SCCHN patients (p<0.05), respectively. The AA homozygote of rs1059369 showed significant association with laryngeal cancer (OR = 3.43) and had joint effects with substance use of ABC in addictive interaction [synergy index (SI) = 1.54-2.85]. The CC homozygotes of rs1054564 and rs1054221 were susceptible to SCCHN (ORs = 2.09 and 2.08) and had joint effects with substance use of cigarette and betel-quid in risk of SCCHN (SI = 1.39-2.01). The risk genotypes of both SNPs were significantly modified by cigarette smoking or betel chewing in oral cancer risk (SI =1.62-1.93) and by alcohol drinking in laryngeal cancer risk (SI =3.84 and 3.85); however, no joint effect was found in the risk of pharyngeal cancer. The GDF15 may influence the incidence and development of SCCHN by joint effects between substance use of ABC and individual genetic variants. 3.
Grazie mille
Elena Alaimo
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